Since the discovery of macrophages in adipose tissue, many laboratories have focused their effort on understanding the contribution of these immune cells to metabolic diseases. Despite great progress in characterizing obesity as a state of low-grade inflammation, very little is known about the multiple phenotypes and functions of macrophages in metabolic tissues. The lack of methods to carefully investigate cell-to-cell variability in macrophage phenotype and to manipulate gene expression in a cell-specific manner has delayed answering these crucial questions. Our lab takes advantage of sophisticated methods to investigate macrophage subpopulations and their function in obesity-associated metabolic complications.
Welcome to Aouadi Lab. We are a research group focusing on immunometabolism in the context of obesity and associated metabolic diseases.
Applications welcome from anyone with expertise in metabolic diseases or metabolic biochemistry. Enthusiasm and curiosity are a prerequisite though 😀 Position can be based in our London, NY or Berlin offices. Msg me if you have any questions. https://twitter.com/NatMetabolism/status/1252605768236445696
#METPHYS2020 @postic20 fantastic talk! Is the alternative splicing of CHREBP regulated in #NAFLD #NASH? In the mice overexpressing CHREBP is NeFA uptake in liver affected (reduced) due to incresase dnl?